Irreversible enzyme inhibitors. XC. candidate active-site-directed irreversible inhibitors of thymidylate synthetase. I. 2-amino-5-(benzenesulfonamidopropyl)-6-methyl-4-pyrimidinol with substituents on the benzene ring
- 作者B. R. Baker; James K. Coward
- 卷第4卷
- 期第2期
- 印刷ISSN0022-152X
- 电子ISSN1943-5193
- 文件大小534.15KB
- 发表时间1967
- DOI10.1002/jhet.5570040206
- 页码195-201
Analogs of tetrahydrofolic acid XXXIII. Hydrophobic bonding to dihydrofolic reductase V. Inhibition by some pyrimidines bridged to benzoic acidB. R. Baker; Beng-Thong Ho; James K. Coward; Daniel V. Santi · 1966
Irreversible enzyme inhibitors. LXXXIX. candidate active-site-directed irreversible inhibitors of dihydrofolic reductase. X. derivatives of 2-amino-5-benzamidopropyl-4-pyrimidinolB. R. Baker; James K. Coward · 1967
Analogs of tetrahydrofolic acid. XXXIX . selective bromoacylation of polyfunctional molecules for synthesis of active-site-directed irreversible enzyme inhibitorsB. R. Baker; Daniel V. Santi; James K. Coward; Howard S. Shapiro; Johannes H. Jordaan · 1966
Irreversible enzyme inhibitors. XCI. candidate active-site directed irreversible inhibitors of thymidylate synthetase. II. 2-amino-6-methyl-5-(p-tolylsulfonamidopropyl)-4-pyrimidinols with N-substituents on the sulfonamide moietyB. R. Baker; James K. Coward · 1967
Analogs of tetrahydrofolic acid XXII. Effects of modification of the bridge between the pyrimidyl and phenyl moieties of 2-amino-5-(3-anilinopropyl) -6-methyl-4-pyrimidinol on inhibition of dihydrofolic reductase and thymidylate synthetase IIIB. R. Baker; James K. Coward · 1965