Enantiomers of HA-966 (3-Amino-1-Hydroxypyrrolid-2-One) Exhibit Distinct Central Nervous System Effects: (+)-HA-966 is a Selective Glycine/N- Methyl-D-Aspartate Receptor Antagonist, But (-)-HA-966 is a Potent γ-Butyrolactone-Like Sedative

L. Singh, A. E. Donald, A. C. Foster, P. H. Hutson, L. L. Iversen, S. D. Iversen, J. A. Kemp, P. D. Leeson, G. R. Marshall, R. J. Oles, T. Priestley, L. Thorn, M. D. Tricklebank, C. A. Vass and B. J. Williams

期刊名称Proceedings of the National Academy of Sciences of the United States of America
作者L. Singh, A. E. Donald, A. C. Foster, P. H. Hutson, L. L. Iversen, S. D. Iversen, J. A. Kemp, P. D. Leeson, G. R. Marshall, R. J. Oles, T. Priestley, L. Thorn, M. D. Tricklebank, C. A. Vass and B. J. Williams
卷第87卷
期第1期
印刷ISSN0027-8424
文件大小1262.52KB
发表时间1990-04
DOI10.2307/2353688
页码347-351

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Enantiomers of HA-966 (3-Amino-1-Hydroxypyrrolid-2-One) Exhibit Distinct Central Nervous System Effects: (+)-HA-966 is a Selective Glycine/N- Methyl-D-Aspartate Receptor Antagonist, But (-)-HA-966 is a Potent γ-Butyrolactone-Like Sedative