Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics
Mark E. Fraley; Robert S. Rubino; William F. Hoffman; Scott R. Hambaugh; Kenneth L. Arrington; Randall W. Hungate; Mark T. Bilodeau; Andrew J. Tebben; Ruth Z. Rutledge; Richard L. Kendall; Rosemary C. McFall; William R. Huckle; Kathleen E. Coll; Kenneth A. Thomas
- 作者Mark E. Fraley; Robert S. Rubino; William F. Hoffman; Scott R. Hambaugh; Kenneth L. Arrington; Randall W. Hungate; Mark T. Bilodeau; Andrew J. Tebben; Ruth Z. Rutledge; Richard L. Kendall; Rosemary C. McFall; William R. Huckle; Kathleen E. Coll; Kenneth A. Thomas
- 卷第12卷
- 期第24期
- 印刷ISSN0960-894X
- 文件大小174.76KB
- 发表时间2002
- DOI10.1016/s0960-894x(02)00827-2
- 页码3537-3541