Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors:  Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity

• 期刊名称Journal of Medicinal Chemistry
• 作者Friesen, Richard W.; Ducharme, Yves; Ball, Richard G.; Blouin, Marc; Boulet, Louise; Côté, Bernard; Frenette, Richard; Girard, Mario; Guay, Daniel; Huang, Zheng; Jones, Thomas R.; Laliberté, France; Lynch, Joseph J.; Mancini, Joseph; Martins, Evelyn; Masson, Paul; Muise, Eric; Pon, Douglas J.; Siegl, Peter K. S.; Styhler, Angela; Tsou, Nancy N.; Turner, Mervyn J.; Young, Robert N.; Girard, Yves
• 卷第46卷
• 期第12期
• 印刷ISSN0022-2623
• 电子ISSN1520-4804
• 文件大小192.64KB
• 发表时间2003-06
• DOI10.1021/jm0204542
• 页码2413-2426