Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1-Methyl-4-phenyltetrahydropyridine Models

Hudkins, Robert L.; Diebold, James L.; Tao, Ming; Josef, Kurt A.; Park, Chung Ho; Angeles, Thelma S.; Aimone, Lisa D.; Husten, Jean; Ator, Mark A.; Meyer, Sheryl L.; Holskin, Beverly P.; Durkin, John T.; Fedorov, Alexander A.; Fedorov, Elena V.; Almo, Steven C.; Mathiasen, Joanne R.; Bozyczko-Coyne, Donna; Saporito, Michael S.; Scott, Richard W.; Mallamo, John P.

期刊名称Journal of Medicinal Chemistry
作者Hudkins, Robert L.; Diebold, James L.; Tao, Ming; Josef, Kurt A.; Park, Chung Ho; Angeles, Thelma S.; Aimone, Lisa D.; Husten, Jean; Ator, Mark A.; Meyer, Sheryl L.; Holskin, Beverly P.; Durkin, John T.; Fedorov, Alexander A.; Fedorov, Elena V.; Almo, Steven C.; Mathiasen, Joanne R.; Bozyczko-Coyne, Donna; Saporito, Michael S.; Scott, Richard W.; Mallamo, John P.
卷第51卷
期第18期
印刷ISSN0022-2623
电子ISSN1520-4804
文件大小751.12KB
发表时间2008-09-25
DOI10.1021/jm8005838
页码5680-5689

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Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1-Methyl-4-phenyltetrahydropyridine Models