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Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on an N,N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats

Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on an N,N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats

David B. Whitman; Christopher D. Cox; Michael J. Breslin; Karen M. Brashear; John D. Schreier; Michael J. Bogusky; Rodney A. Bednar; Wei Lemaire; Joseph G. Bruno; George D. Hartman; Duane R. Reiss ; C. Meacham Harrell; Richard L. Kraus; Yuxing Li; Susan L. Garson; Scott M. Doran; Thomayant Prueksaritanont; Chunze Li; Christopher J. Winrow; Kenneth S. Koblan; John J. Renger; Paul J. Coleman
  • 作者David B. Whitman; Christopher D. Cox; Michael J. Breslin; Karen M. Brashear; John D. Schreier; Michael J. Bogusky; Rodney A. Bednar; Wei Lemaire; Joseph G. Bruno; George D. Hartman; Duane R. Reiss ; C. Meacham Harrell; Richard L. Kraus; Yuxing Li; Susan L. Garson; Scott M. Doran; Thomayant Prueksaritanont; Chunze Li; Christopher J. Winrow; Kenneth S. Koblan; John J. Renger; Paul J. Coleman
  • 卷第4卷
  • 期第7期
  • 印刷ISSN1860-7179
  • 电子ISSN1860-7187
  • 文件大小417.82KB
  • 发表时间2009
  • DOI10.1002/cmdc.200900069
  • 页码1069-1074
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