In Vitro Intrinsic Clearance-Based Optimization of
<i>N</i>
<sup>3</sup>
-Phenylpyrazinones as Corticotropin-Releasing Factor-1 (CRF
<sub/>1</sub>
) Receptor Antagonists

In Vitro Intrinsic Clearance-Based Optimization of N ³ -Phenylpyrazinones as Corticotropin-Releasing Factor-1 (CRF ₁ ) Receptor Antagonists

Hartz, Richard A.; Ahuja, Vijay T.; Rafalski, Maria; Schmitz, William D.; Brenner, Allison B.; Denhart, Derek J.; Ditta, Jonathan L.; Deskus, Jeffrey A.; Yue, Eddy W.; Arvanitis, Argyrios G.; Lelas, Snjezana; Li, Yu-Wen; Molski, Thaddeus F.; Wong, Harvey; Grace, James E.; Lentz, Kimberley A.; Li, Jianqing; Lodge, Nicholas J.; Zaczek, Robert; Combs, Andrew P.; Olson, Richard E.; Mattson, Ronald J.; Bronson, Joanne J.; Macor, John E.

期刊名称Journal of Medicinal Chemistry
作者Hartz, Richard A.; Ahuja, Vijay T.; Rafalski, Maria; Schmitz, William D.; Brenner, Allison B.; Denhart, Derek J.; Ditta, Jonathan L.; Deskus, Jeffrey A.; Yue, Eddy W.; Arvanitis, Argyrios G.; Lelas, Snjezana; Li, Yu-Wen; Molski, Thaddeus F.; Wong, Harvey; Grace, James E.; Lentz, Kimberley A.; Li, Jianqing; Lodge, Nicholas J.; Zaczek, Robert; Combs, Andrew P.; Olson, Richard E.; Mattson, Ronald J.; Bronson, Joanne J.; Macor, John E.
卷第52卷
期第14期
印刷ISSN0022-2623
电子ISSN1520-4804
文件大小1051.10KB
发表时间2009-07-23
DOI10.1021/jm900302q
页码4161-4172

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In Vitro Intrinsic Clearance-Based Optimization of N 3 -Phenylpyrazinones as Corticotropin-Releasing Factor-1 (CRF 1 ) Receptor Antagonists

In Vitro Intrinsic Clearance-Based Optimization of N ³ -Phenylpyrazinones as Corticotropin-Releasing Factor-1 (CRF ₁ ) Receptor Antagonists