<i>In silico</i>
and
<i>in vitro</i>
evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization

In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization

Kamola, Piotr J.; Kitson, Jeremy D. A.; Turner, Gemma; Maratou, Klio; Eriksson, Sofie; Panjwani, Aliza; Warnock, Linda C.; Douillard Guilloux, Gaelle A.; Moores, Kitty; Koppe, Emma L.; Wixted, William E.; Wilson, Paul A.; Gooderham, Nigel J.; Gant, Timothy W.; Clark, Kenneth L.; Hughes, Stephen A.; Edbrooke, Mark R.; Parry, Joel D.

期刊名称Nucleic Acids Research
作者Kamola, Piotr J.; Kitson, Jeremy D. A.; Turner, Gemma; Maratou, Klio; Eriksson, Sofie; Panjwani, Aliza; Warnock, Linda C.; Douillard Guilloux, Gaelle A.; Moores, Kitty; Koppe, Emma L.; Wixted, William E.; Wilson, Paul A.; Gooderham, Nigel J.; Gant, Timothy W.; Clark, Kenneth L.; Hughes, Stephen A.; Edbrooke, Mark R.; Parry, Joel D.
印刷ISSN0305-1048
电子ISSN1362-4962
文件大小1576.15KB
发表时间2015-09-03
DOI10.1093/nar/gkv857

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In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization