Discovery of tetrahydro-pyrazolo-pyridine as sphingosine 1-phosphate receptor 3 (S1P
<sub/>3</sub>
)-sparing S1P
<sub/>1</sub>
agonists active at low oral doses

Discovery of tetrahydro-pyrazolo-pyridine as sphingosine 1-phosphate receptor 3 (S1P ₃ )-sparing S1P ₁ agonists active at low oral doses

Demont, Emmanuel H; Bailey, James M.; Bit, Rino A; Brown, Jack A; Campbell, Colin A; Deeks, Nigel; Dowell, Simon J.; Eldred, Colin; Gaskin, Pam; Gray, James R. J.; Haynes, Andrea; Hirst, David J.; Holmes, Duncan S.; Kumar, Umesh; Morse, Mary A.; Osborne, Greg J.; Renaux, Jessica F.; Seal, Gail A. L.; Smethurst, Chris A.; Taylor, Simon J; Watson, Robert; Willis, Robert; Witherington, Jason

期刊名称Journal of Medicinal Chemistry
作者Demont, Emmanuel H; Bailey, James M.; Bit, Rino A; Brown, Jack A; Campbell, Colin A; Deeks, Nigel; Dowell, Simon J.; Eldred, Colin; Gaskin, Pam; Gray, James R. J.; Haynes, Andrea; Hirst, David J.; Holmes, Duncan S.; Kumar, Umesh; Morse, Mary A.; Osborne, Greg J.; Renaux, Jessica F.; Seal, Gail A. L.; Smethurst, Chris A.; Taylor, Simon J; Watson, Robert; Willis, Robert; Witherington, Jason
印刷ISSN0022-2623
电子ISSN1520-4804
文件大小887.91KB
发表时间2016-01-11
DOI10.1021/acs.jmedchem.5b01512

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Discovery of tetrahydro-pyrazolo-pyridine as sphingosine 1-phosphate receptor 3 (S1P 3 )-sparing S1P 1 agonists active at low oral doses

Discovery of tetrahydro-pyrazolo-pyridine as sphingosine 1-phosphate receptor 3 (S1P ₃ )-sparing S1P ₁ agonists active at low oral doses