Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the Heat Shock Factor 1 (HSF1) stress pathway and CDK9.

Rye, Carl; Chessum, Nicola; Lamont, Scott; Pike, Kurt Gordon; Faulder, Paul F.; Demeritt, Julie; Kemmitt, Paul D; Tucker, Julie; Zani, Lorenzo; Cheeseman, Matthew; Isaac, Rosie; Goodwin, Louise; Boros, Joanna; Raynaud, Florence; Hayes, Angela; Henley, Alan; de Billy, Emmanuel; Lynch, Chris; Sharp, Swee; te Poele, Robert; O Fee, Lisa; Foote, KM; Green, Stephen; Workman, Paul; Jones, Keith

期刊名称Med. Chem. Commun.
作者Rye, Carl; Chessum, Nicola; Lamont, Scott; Pike, Kurt Gordon; Faulder, Paul F.; Demeritt, Julie; Kemmitt, Paul D; Tucker, Julie; Zani, Lorenzo; Cheeseman, Matthew; Isaac, Rosie; Goodwin, Louise; Boros, Joanna; Raynaud, Florence; Hayes, Angela; Henley, Alan; de Billy, Emmanuel; Lynch, Chris; Sharp, Swee; te Poele, Robert; O Fee, Lisa; Foote, KM; Green, Stephen; Workman, Paul; Jones, Keith
印刷ISSN2040-2503
电子ISSN2040-2511
文件大小1882.26KB
发表时间2016
DOI10.1039/C6MD00159A

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Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the Heat Shock Factor 1 (HSF1) stress pathway and CDK9.