Fluorine-Substituted Pyrrolo[2,3-
<i>d</i>
]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of
<i>de Novo</i>
Purine Nucleotide Biosynthesis

Fluorine-Substituted Pyrrolo[2,3- d ]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis

Ravindra, Manasa; Wilson, Mike R.; Tong, Nian; O’Connor, Carrie; Karim, Mohammad; Polin, Lisa; Wallace-Povirk, Adrianne; White, Kathryn; Kushner, Juiwanna; Hou, Zhanjun; Matherly, Larry H.; Gangjee, Aleem

期刊名称Journal of Medicinal Chemistry
作者Ravindra, Manasa; Wilson, Mike R.; Tong, Nian; O’Connor, Carrie; Karim, Mohammad; Polin, Lisa; Wallace-Povirk, Adrianne; White, Kathryn; Kushner, Juiwanna; Hou, Zhanjun; Matherly, Larry H.; Gangjee, Aleem
印刷ISSN0022-2623
电子ISSN1520-4804
文件大小4186.46KB
发表时间2018-04-27
DOI10.1021/acs.jmedchem.8b00408

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Fluorine-Substituted Pyrrolo[2,3- d ]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis