Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression

• 期刊名称Journal of Medicinal Chemistry
• 作者Qin, Chong; Hu, Yang; Zhou, Bing; Fernandez-Salas, Ester; Yang, Chao-Yie; Liu, Liu; McEachern, Donna; Przybranowski, Sally; Wang, Mi; Stuckey, Jeanne; Meagher, Jennifer; Bai, Longchuan; Chen, Zhuo; Lin, Mei; Yang, Jiuling; Ziazadeh, Danya N.; Xu, Fuming; Hu, Jiantao; Xiang, Weiguo; Huang, Liyue; Li, Siwei; Wen, Bo; Sun, Duxin; Wang, Shaomeng
• 印刷ISSN0022-2623
• 电子ISSN1520-4804
• 文件大小9728.72KB
• 发表时间2018-07-18
• DOI10.1021/acs.jmedchem.8b00506