Discovery of a covalent inhibitor of KRASG12C (AMG 510) for the treatment of solid tumors

Lanman, Brian A; Allen, Jennifer R.; Allen, John G.; Amegadzie, Albert K; Ashton, Kate S.; Booker, Shon K.; Chen, Jian Jeffrey; Chen, Ning; Frohn, Michael J; Goodman, Guy; Kopecky, David J; Liu, Longbin; Lopez, Patricia; Low, Jonathan D; Ma, Vu; Minatti, Ana Elena; Nguyen, Thomas T; Nishimura, Nobuko; Pickrell, Alexander J.; Reed, Anthony B.; Shin, Youngsook; Siegmund, Aaron; Tamayo, Nuria A.; Tegley, Christopher M; Walton, Mary C; Wang, Hui-Ling; Wurz, Ryan P.; Xue, May; Yang, Kevin C; Achanta, Pragathi; Bartberger, Michael D.; Canon, Jude; Hollis, L Steven; McCarter, John D; Mohr, Christopher; Rex, Karen; Saiki, Anne Y; San Miguel, Tisha; Volak, Laurie; Wang, Kevin H; Whittington, Douglas A.; Zech, Stephan G; Lipford, J. Russell; Cee, Victor J.

期刊名称Journal of Medicinal Chemistry
作者Lanman, Brian A; Allen, Jennifer R.; Allen, John G.; Amegadzie, Albert K; Ashton, Kate S.; Booker, Shon K.; Chen, Jian Jeffrey; Chen, Ning; Frohn, Michael J; Goodman, Guy; Kopecky, David J; Liu, Longbin; Lopez, Patricia; Low, Jonathan D; Ma, Vu; Minatti, Ana Elena; Nguyen, Thomas T; Nishimura, Nobuko; Pickrell, Alexander J.; Reed, Anthony B.; Shin, Youngsook; Siegmund, Aaron; Tamayo, Nuria A.; Tegley, Christopher M; Walton, Mary C; Wang, Hui-Ling; Wurz, Ryan P.; Xue, May; Yang, Kevin C; Achanta, Pragathi; Bartberger, Michael D.; Canon, Jude; Hollis, L Steven; McCarter, John D; Mohr, Christopher; Rex, Karen; Saiki, Anne Y; San Miguel, Tisha; Volak, Laurie; Wang, Kevin H; Whittington, Douglas A.; Zech, Stephan G; Lipford, J. Russell; Cee, Victor J.
印刷ISSN0022-2623
电子ISSN1520-4804
文件大小1572.60KB
发表时间2019-12-10
DOI10.1021/acs.jmedchem.9b01180

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Discovery of a covalent inhibitor of KRASG12C (AMG 510) for the treatment of solid tumors