Discovery of (2
<i>R</i>
)-
<i>N</i>
-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1
<i>H</i>
-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Discovery of (2 R )- N -[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1 H -indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

Su, Qibin; Banks, Erica; Bebernitz, Geraldine; Bell, Kirsten; Borenstein, Cassandra F.; Chen, Huawei; Chuaqui, Claudio E.; Deng, Nanhua; Ferguson, Andrew D.; Kawatkar, Sameer; Grimster, Neil P.; Ruston, Linette; Lyne, Paul D.; Read, Jon A.; Peng, Xianyou; Pei, Xiaohui; Fawell, Stephen; Tang, Zhanlei; Throner, Scott; Vasbinder, Melissa M.; Wang, Haoyu; Winter-Holt, Jon; Woessner, Richard; Wu, Allan; Yang, Wenzhan; Zinda, Michael; Kettle, Jason G.

期刊名称Journal of Medicinal Chemistry
作者Su, Qibin; Banks, Erica; Bebernitz, Geraldine; Bell, Kirsten; Borenstein, Cassandra F.; Chen, Huawei; Chuaqui, Claudio E.; Deng, Nanhua; Ferguson, Andrew D.; Kawatkar, Sameer; Grimster, Neil P.; Ruston, Linette; Lyne, Paul D.; Read, Jon A.; Peng, Xianyou; Pei, Xiaohui; Fawell, Stephen; Tang, Zhanlei; Throner, Scott; Vasbinder, Melissa M.; Wang, Haoyu; Winter-Holt, Jon; Woessner, Richard; Wu, Allan; Yang, Wenzhan; Zinda, Michael; Kettle, Jason G.
印刷ISSN0022-2623
电子ISSN1520-4804
文件大小756.08KB
发表时间2020-04-28
DOI10.1021/acs.jmedchem.9b01392

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Discovery of (2 R )- N -[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1 H -indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor